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Alleged triple killer, Jordan Monaghan, 30, is accused of smothering his daughter, Ruby, aged 24 days, on New Year's Day, 2013, eight months before also smothering his son, Logan, aged 21 months.

He also denies the murder of his new partner, Evie Adams, 23, six years later in October 2019, by giving her an overdose of tramadol and diazepam. 

The jury was told today that Monaghan would harm both Logan and Ruby when they were left in his care and when his relationship with their mother, Laura Gray, was struggling.

Duncan Smith, QC, prosecuting, said each time Laura Gray threatened to leave, Monaghan caused the children to be ill so as to create a situation where she would feel obliged to stay.




Monaghan, of Blackburn, is alleged to have smothered Ruby in 2013 before murdering Logan (both pictured) eight months later. Monaghan denies the two counts of murder and is on trial

Questioning Monaghan during the trial at Preston Crown Court, Mr Smith said: 'Your relationship with Laura Gray was important to you.

Monaghan replied: 'Yes, to some extent. Not more important than my children.'

Mr Smith said instances where Monaghan called 111 to say Logan had swallowed paracetamol or, on a separate occasion, that Ruby was struggling to breathe were orchestrated to save his relationship.

Mr Smith said: 'Logan's sudden illness meant your relationship would continue.

'Once more what had happened to Logan meant Laura Gray stayed in a relationship with you. You created a situation to keep you together.'

The court also heard that Ruby collapsed on December 29 when she was struggling to breathe and the paramedics were contacted.

Mr Smith said: 'On your account those changes in Ruby came out of nowhere.

'They came about because you had restricted her ability to breathe, Mr Monaghan. How did you restrict her ability to breathe?'




Accused Jordan Monaghan pictured with Laura Gray - the mother of Ruby and Logan - in 2013

Monaghan denied harming Rugby.

Mr Smith said Mr Monaghan was 'remarkably' calm during all the calls to the medical services.

Mr Monaghan replied: 'I was normal, yes. I was worried but normal.'

Mr Smith added: 'Were you normal because what had happened was neither a shock nor a surprise?'




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Mr Smith then told the jury that when Ruby died on New Year's Day 2013, Monaghan had been alone with his three-week-old daughter for more than an hour.

He said: 'You killed her by restricting her breathing, haven't you?'

Ruby died at home on New Year's Day in 2013, and her brother Logan died eight months later on August 17.

The court had previously heard that Miss Gray found her son Logan dead in his buggy after Monaghan had taken him swimming.




Jordan Monaghan, 30, denies three counts of murder, two counts of attempted murder and two counts of cruelty to a child and is standing trial at Preston Crown Court (pictured)

Earlier in the day, the jury heard how Evie Adams, who the prosecution say was killed by Monaghan, had sent him a text threatening to kill herself on the day of her death.

It is the prosecution's case that Monaghan bought the prescription drugs Tramadol and Diazepam on the black market and fed to Miss Adams 'covertly without her agreement or knowledge'.

During the trial today, the jury was told 23-year-old Miss Adams had messaged Monaghan saying: 'Jordan, I really don't want to be here anymore. I have taken some drugs and I don't want help.' 

Monaghan told the jury he was initially concerned Miss Adams had taken an overdose.

He said: 'I thought she had taken some drugs so I went and spoke to her. I asked her why she had taken some drugs and she said she hadn't taken anything.

'I asked her why she sent the message and she said it was like the couple of days before where she said she was having a bad day.

'I asked her if she was going to take any and she said "no".'

The hearing heard how two days previously, Miss Adams had also threatened to commit suicide.




Jordan Monaghan, of Blackburn, is also accused of murdering his new partner, Evie Adams (pictured), 23, by giving her an overdose of Tramadol and diazepam on October 24 in 2019

She had texted Monaghan: 'I took all them (sic) tablets you gave me today as well as just took 10 co-codamol and 10 paracetamol because I don't want to live no more.

'And I will carry on taking more.'

Monaghan told Preston Crown Court the pills Miss Adams was referring to was the paracetamol he had bought for her previously.

The jury was told how internet searches had been found on Miss Adams' phone which included 'How many tablets do I have to take to go to hospital?'; 'What medication do I have to take to overdose?'; and 'Help for suicidal thoughts'.

Monaghan denies murdering Miss Adams in October 2019.

The 30-year-old told the court that on the day of Miss Adams' death, a doctor had visited the house.

He said: 'Evie had told me the doctor had been out to see her. She still had stomach flu and she said he had prescribed her tramadol.'

Taking the stand, Monaghan also told the court how he was 'in a mess' when returning home from work to discover Miss Adams was not breathing.

Defending, Ben Myers, QC, asked: 'Had you seen anything round about the bedroom or any area that was at all relevant in what had happened to Evie?'

Monaghan said: 'The paramedic asked me if she could have taken anything and he asked me to have a look to see if there was anything about in the house.

'He asked me to check about to see if there was anything she could have taken. I did check and outside the bedroom were some empty packets of paracetamol, which I picked up and passed to him.'

Monaghan added: 'The police asked us if there was any other medication that she could have taken.

'That's when we told them, there was a strip of tramadol and that there were four missing from it, so she had obviously taken four.'

Monaghan denied supplying the tramadol and said he believed the doctor had prescribed it.

He replied 'definitely not' when asked if he had contributed in any way to Evie's death. 

Monaghan, of Blackburn, denies three counts of murder, two counts of attempted murder and two counts of cruelty to a child, all between January 1 2013 and October 24 2019. 

The trial continues. 

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June 14 (Reuters) - Avenue Therapeutics Inc said on Monday the U.S. Food and Drug Administration (FDA) declined to approve its intravenous formulation of painkiller tramadol for a second time, sending its shares tumbling about 38%.

The health regulator in October declined to approve the intravenous formulation of the painkiller, stating it was not safe for the intended population.

The agency said on Monday the delayed and unpredictable onset of analgesia - relief from pain - with intravenous (IV) tramadol did not support its benefit as a monotherapy to treat patients with acute pain.

There was also insufficient data to support that IV tramadol was safe and effective in combination with other drugs, FDA said in its decision that came in more than two months after the scheduled date of April 12.

H.C. Wainwright analyst Joseph Pantginis, however, says that IV tramadol could still have a path forward.

The FDA did not mention any "chemistry, manufacturing and controls (CMC)" issues in its complete response letter, Avenue said, adding that it disagreed with the agency's decision and would continue to seek regulatory approval for IV tramadol.

Tramadol was approved in the United States in 1995 as a non-controlled analgesic, under the trade name of Ultram, to be sold by drugmaker Johnson & Johnson. (Reporting by Trisha Roy in Bengaluru; Editing by Rashmi Aich and Shinjini Ganguli)

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A staggering 21 percent of Americans contend with chronic pain, an umbrella term that encompasses a range of debilitating conditions.

Over one in five Americans experienced chronic pain between 2019 and 2021, new data from the Centers for Disease Control and Prevention (CDC) shows. 

Doctors have many tools in their arsenal to treat conditions that cause severe, persistent pain, such as chronic back pain and frequent migraines. One of those tools is opioid painkillers which, while effective, carry a substantial risk of addiction.

The introduction of euphoria-inducing prescription opioids sparked a long-running trend of overzealous prescribing by profit-motivated doctors and drugmakers. At one point, the nationwide opioid prescribing rate hit 81 for every 100 persons. 

The standard of care has shifted to favor non-pharmaceutical treatments for pain as an alternative to risky medications. DailyMail.com broke down some of these treatments for some of the most common causes of life-altering chronic pain.




Between 2019 and 2021, the prevalence of chronic pain among American adults ranged from about 20 percnet to nearly 22 percent and the prevalence of high-impact chronic pain ranged from about seven percent to eight percent 

The new report from the CDC published Thursday estimates that 51.5 million adults are living with chronic pain. Among them, 17.1 experienced what could be described as 'high-impact' chronic pain defined as chronic pain that also limited daily life or work activities on most days or every day during the previous 3 months.

The researchers drew on data collected between 2019 and 2021 in an annual poll. 

When compared to data compiled in 2006, it appears that chronic pain is becoming more common. The CDC reported then that one in 10 people said their pain persisted for a year or more. 

While the CDC researchers did not say why so many Americans are in pain, outside experts have speculated multiple reasons.

The nation is experiencing a weight crisis, with 40 percent of adults obese and 70 percent overweight. Unhealthy weight is linked to chronic pain.

Experts also say that the lack of activity and sedentary lifestyles lived by many Americans is causing harm.

A University of Georgia study published last year found 75 percent of Americans do not meet recommended activity levels. 

Many also eat diets consisting heavily of highly processed foods, further linked to poor overall health and chronic pain _ with recent data showing 13 percent of the population is addicted to the chemical-rich foods.

The report sheds light on the size of the population that has likely been confronted with the notion of taking prescription painkillers such as oxycodone to treat their lasting pain. 

But the drugs are notoriously dangerous and carry a major risk of addiction.

Fatal overdoses attributable to opioids surpassed 80,000 in 2021, roughly 70 percent of that year's total.



Chronic back pain
More than 16 million US adults - eight percent of the population - experience chronic back pain. 

The condition can severely hamper a person's daily life, causing a constant, dull ache or sharp, stabbing pains.

It can be worsened, perhaps counterintuitively, by resting too much. 

This is because lying prone for an extended period of time puts pressure on the spine and can lead to stiff or sore muscles.

Doctors discourage resting for more than a day or two and encourage people to get moving. 

Stretching is a good place to start. While not a cure-all, yoga poses can be highly effective at providing temporary pain relief.

A common yoga stretch called child's pose stretches spinal extensors, muscles attached to the back of the spine that allow us to stand and lift objects. 

The pose also promotes blood circulation.

Swimming, or indeed any moderate activity in water is also believed to be highly beneficial. 

A 2009 report by Turkish scientists published in the journal Spine found that water exercises improved disabilities and quality of life better than other types of exercise performed outside of the water.




Back pain can actually be worsened by resting too much, because because lying prone for an extended period of time puts pressure on the spine

A separate 2018 meta-analysis of eight studies published in the American Journal of Physical Medicine & Rehabilitation concluded: _Aquatic exercise statistically significantly decreased the VAS scores [to measure of pain intensity] and increased physical function.

'These results suggested that aquatic exercise played a positive role in improving in pain and physical health-related quality of life.'

Finally, experts recommend making some small changes to sleep positioning as poor sleep is well known to aggravate back pain.

People who primarily sleep on their backs should slide a pillow under their knees, while side-sleepers should put a pillow between their knees to keep the spine in a neutral position and relieve strain on their back.

Arthritis



_Arthritis' generally refers to more than 100 joint diseases including the most common types, osteoarthritis and rheumatoid arthritis

Arthritis, a chronic condition marked by stiff, swelling joints which lead to lead to pain that worsens with age, affects nearly 59 million Americans.

The term _arthritis' generally refers to more than 100 joint diseases, including the most common types, osteoarthritis and rheumatoid arthritis.

Osteoarthritis causes a breakdown of cartilage, hard tissue that covers the edges of bones where they form the joints. It's commonly referred to as _wear and tear' arthritis.

The chronic pain that it causes is attributed to years of cartilage erosion, which leads to inflammation in joints used daily, such as the knees, hips, and shoulders. 

Sufferers could benefit from physical therapy sessions with a licensed professional, experts believe.

Physical therapy involves exercises that strengthen muscles surrounding the joints, relieving some of the burden on the cartilage and bone. 

The therapist may use equipment, such as foam rollers to improve hip pain in patients with hip osteoarthritis, or resistance bands, which have been shown to help people relieve arthritis pain in their knees.

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